# Unmasking Distal Renal Tubular Acidosis in a Young Female: A Case of Metabolic Acidosis With Hypokalemic Paraparesis

**Authors:** GKM Rashik Uzzaman, Muhammad Mohsin Isar, Sultana Jannatun Nahar, Naeem Rana, Taslima Moonmoon

PMC · DOI: 10.7759/cureus.85193 · Cureus · 2025-06-01

## TL;DR

A young woman with severe muscle weakness and low potassium was diagnosed with a rare kidney disorder and improved with treatment.

## Contribution

Highlights the importance of recognizing type 1 dRTA in young patients with hypokalemic paralysis.

## Key findings

- Patient showed normal anion gap metabolic acidosis and elevated urinary pH.
- Treatment with potassium and bicarbonate led to significant improvement.
- Early diagnosis is critical to prevent complications and enable recovery.

## Abstract

This case report aims to highlight the diagnostic challenge and clinical significance of type 1 distal renal tubular acidosis (dRTA) in young patients presenting with hypokalemic paralysis. A 19-year-old female presented with vomiting, progressive lower limb weakness, and severe hypokalemia. Investigations revealed normal anion gap metabolic acidosis, elevated urinary pH, and renal potassium loss. After ruling out other causes, a diagnosis of dRTA was made. She responded well to potassium and bicarbonate therapy. Early recognition and treatment are essential to prevent complications and ensure full recovery.

## Linked entities

- **Diseases:** distal renal tubular acidosis (MONDO:0015827), metabolic acidosis (MONDO:0000440)

## Full-text entities

- **Diseases:** Distal Renal Tubular Acidosis (MESH:D000141), Metabolic Acidosis (MESH:D000138), weakness (MESH:D018908), hypokalemia (MESH:D007008), vomiting (MESH:D014839), Hypokalemic Paraparesis (MESH:D020335), hypokalemic paralysis (MESH:D020514), potassium loss (MESH:D011191)
- **Chemicals:** bicarbonate (MESH:D001639), potassium (MESH:D011188)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12212614/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12212614/full.md

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Source: https://tomesphere.com/paper/PMC12212614