# Editorial: Mechanisms of early intracellular signaling in T lymphocytes

**Authors:** Enrique Aguado, Mikel M. Arbulo-Echevarria, Ewoud B. Compeer

PMC · DOI: 10.3389/fimmu.2025.1638330 · 2025-06-17

## Full-text entities

- **Genes:** Cd3e (CD3 antigen, epsilon polypeptide) [NCBI Gene 12501] {aka CD3, CD3epsilon, T3e}, ORAI1 (ORAI calcium release-activated calcium modulator 1) [NCBI Gene 84876] {aka CRACM1, IMD9, ORAT1, TAM2, TMEM142A}, Zap70 (zeta-chain (TCR) associated protein kinase) [NCBI Gene 22637] {aka Srk, ZAP-70, mrtle, mur}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, Stam (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1) [NCBI Gene 20844] {aka STAM1}, Stat3 (signal transducer and activator of transcription 3) [NCBI Gene 20848] {aka 1110034C02Rik, Aprf}, Plcg1 (phospholipase C, gamma 1) [NCBI Gene 18803] {aka Cded, Plc-1, Plc-gamma1, Plcg-1}, Ifng (interferon gamma) [NCBI Gene 15978] {aka IFN-g, If2f, Ifg}, Hgs (HGF-regulated tyrosine kinase substrate) [NCBI Gene 15239] {aka Hgr, Hrs, ZFYVE8, tn}, Lcp2 (lymphocyte cytosolic protein 2) [NCBI Gene 16822] {aka SLP-76, SLP76, m1Khoe, twm}, Src (src proto-oncogene, non-receptor tyrosine kinase) [NCBI Gene 20779] {aka pp60c-src}, Malt1 (MALT1 paracaspase) [NCBI Gene 240354] {aka A630046N12, D430033E09Rik, Pcasp1}, ANO9 (anoctamin 9) [NCBI Gene 338440] {aka PIG5, TMEM16J, TP53I5}, Stam2 (signal transducing adaptor molecule (SH3 domain and ITAM motif) 2) [NCBI Gene 56324] {aka 1200004O12Rik, 5730456G07Rik, Hbp}, Lat (linker for activation of T cells) [NCBI Gene 16797] {aka p36-38, pp36}, Zc3h12a (zinc finger CCCH type containing 12A) [NCBI Gene 230738] {aka MCPIP, MCPIP-1, Mcpip1, Reg1}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}, STIM1 (stromal interaction molecule 1) [NCBI Gene 6786] {aka D11S4896E, GOK, IMD10, STRMK, TAM, TAM1}, Lck (lck proto-oncogene, Src family tyrosine kinase) [NCBI Gene 16818] {aka Hck-3, Lsk, Lskt, p56<lck>, p56Lck}, Mapk1 (mitogen-activated protein kinase 1) [NCBI Gene 26413] {aka 9030612K14Rik, ERK, Erk2, MAPK2, PRKM2, Prkm1}, Ptprc (protein tyrosine phosphatase receptor type C) [NCBI Gene 19264] {aka B220, CD45R, Cd45, L-CA, Ly-5, Lyt-4}, Klf2 (Kruppel-like transcription factor 2 (lung)) [NCBI Gene 16598] {aka Lklf}, Trav6-3 (T cell receptor alpha variable 6-3) [NCBI Gene 328483] {aka Gm13948, Gm193, Gm4, TCR}, Rc3h1 (RING CCCH (C3H) domains 1) [NCBI Gene 381305] {aka 5730557L09Rik, Gm551, mKIAA2025}, Fyn (Fyn proto-oncogene, Src family tyrosine kinase) [NCBI Gene 14360]
- **Diseases:** immune disorders (MESH:D007154), infection (MESH:D007239), cancer (MESH:D009369), experimental autoimmune encephalomyelitis (MESH:D004681)
- **Chemicals:** Calcium (MESH:D002118), Ca2+ (-)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Enterovirus C (no rank) [taxon 138950]
- **Cell lines:** Jurkat T — Homo sapiens (Human), Childhood T acute lymphoblastic leukemia, Cancer cell line (CVCL_0065)

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Source: https://tomesphere.com/paper/PMC12208825