# Anesthetic effect of articaine and lidocaine in tooth extraction

**Authors:** Abhigyan Manas, Archana H Lanje (Misurya), Savita Singh, Jagadeesh K.N, Subham Patra, Prasanna T.R, Santosh T, Vaibhav Awinashe

PMC · DOI: 10.6026/973206300210297 · 2025-03-31

## TL;DR

This study compares the anesthetic effects of 4% articaine and 2% lidocaine during tooth extraction, finding articaine to be faster and longer-lasting.

## Contribution

The study provides empirical evidence on the superior onset and duration of 4% articaine compared to 2% lidocaine in dental procedures.

## Key findings

- 4% articaine had a shorter onset of action compared to 2% lidocaine.
- Articaine provided a longer duration of anesthesia than lidocaine.
- Fewer patients required re-anesthetization with articaine.

## Abstract

The safety and efficiency of 4% articaine compared to 2% lidocaine for tooth extraction is of interest to dentists. Hence, a total of
30 patients requiring premolar tooth extraction for orthodontics reason were randomly divided into 2 groups namely (1) articaine and (2)
lidocaine. Parameters such as onset of action, duration of anaesthesia and need to re-anesthetize at the surgical zone are evaluated.
Pain evaluation was done with visual analog scale (VAS). Data shows that 4% articaine had a shorter onset of action and longer duration
of anaesthesia compared to lidocaine.

## Linked entities

- **Chemicals:** articaine (PubChem CID 32170), lidocaine (PubChem CID 3676)

## Full-text entities

- **Diseases:** Pain (MESH:D010146)
- **Chemicals:** articaine (MESH:D002355), lidocaine (MESH:D008012)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12208266