Unveiling dickkopf-1 in periodontitis progression- A review
Bawatharani Maharavi, Jaideep Mahendra, Prashanthi Prakash
TL;DR
This paper reviews how the protein Dickkopf-1 contributes to periodontitis by affecting bone health and suggests it could be a target for treatment.
Contribution
The paper provides a novel review of Dickkopf-1's role in periodontitis and its potential as a therapeutic target.
Findings
Dickkopf-1 inhibits Wnt signaling, reducing osteoblast activity and promoting bone resorption in periodontitis.
Neutralizing Dickkopf-1 may support bone regeneration and improve alveolar bone health in periodontitis patients.
Abstract
Periodontitis is a chronic bacterial infection causing tissue damage, bone loss and tooth mobility and thus, impacting quality of life. It is influenced by factors like plaque, genetics and immune response, driving inflammation and tissue destruction. Dickkopf-1 inhibits the wingless-related integration site (Wnt) signalling pathway, reducing osteoblast activity and promoting osteoclast formation, leading to bone resorption. Neutralizing Dickkopf-1 activity may facilitate bone regeneration, suggesting its potential as a target for periodontitis treatment. Therefore, it is of interest to review the role of Dickkopf-1 in periodontitis for understanding its impact on alveolar bone resorption highlighting its therapeutic potential in improving alveolar bone health.
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Taxonomy
TopicsFibroblast Growth Factor Research · Wnt/β-catenin signaling in development and cancer · Connective tissue disorders research