Characterization of clear cell - Renal cell carcinoma using neutrophil - Lymphocyte ratio

TL;DR

This study shows that the neutrophil-lymphocyte ratio can predict tumor size and vein invasion in kidney cancer patients.

Contribution

The study identifies the neutrophil-lymphocyte ratio as a novel prognostic marker for clear cell renal cell carcinoma.

Findings

Elevated neutrophil-lymphocyte ratio was significantly linked to larger tumor size.

High neutrophil-lymphocyte ratio correlated with increased renal vein invasion.

A cut-off of 2.7 effectively distinguished normal from elevated ratios.

Abstract

The features of tumour in clear cell - renal cell carcinoma are evaluated using neutrophil - lymphocyte ratio for its prognosis.
Hence, 186 clear cell-renal cell carcinoma patients with documented neutrophil lymphocyte ratio were obtained. Depending on the features
of the lesion, patients underwent either a partial or radical nephrectomy and characteristics were studied in relation to normal or high
neutrophil - lymphocyte ratio with a cut-off of 2.7. Of the 186 patients studied, 131 had a normal neutrophil lymphocyte ratio (<2.7),
while 55 presented with an elevated neutrophil lymphocyte ratio (≥2.7). Elevated neutrophil lymphocyte ratio was significantly
associated with both tumor size and renal vein invasion, with a p-value of less than 0.001. Thus, the neutrophil lymphocyte ratio is a
valuable metric for assessing renal vein extension and predicting tumour size.