TL;DR
This paper explores how alcohol affects gene activity, DNA methylation, and metabolism in human embryonic cells during early development.
Contribution
The study provides new insights into the molecular effects of alcohol on human embryonic cells during gastrulation.
Findings
Alcohol exposure alters the transcriptome of gastrulating human embryonic cells.
Changes in DNA methylation patterns are observed following alcohol exposure.
Metabolomic shifts indicate disrupted metabolic pathways due to alcohol.
Abstract
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Essi Wallén is first author on ‘ Effects of alcohol on the transcriptome, methylome and metabolome of in vitro gastrulating human embryonic cells’, published in DMM. Essi is a PhD researcher in the lab of Nina Kaminen-Ahola at Environmental Epigenetics Laboratory, Department of Medical and Clinical Genetics, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland, investigating how alcohol influences the early human development.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsPrenatal Substance Exposure Effects · Genetic Syndromes and Imprinting · Epigenetics and DNA Methylation