# First person – So-Hyun Lee

PMC · DOI: 10.1242/dmm.052504 · 2025-06-20

## TL;DR

This paper presents an interview with So-Hyun Lee, who studied a zebrafish model of epilepsy and found that a specific mutation responds to valproic acid.

## Contribution

The study identifies a zebrafish model with a slc25a22a mutation that exhibits seizures and responds to valproic acid.

## Key findings

- Zebrafish lacking slc25a22a show spontaneous seizures.
- Valproic acid, an anti-seizure medication, is effective in this zebrafish model.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. So-Hyun Lee is first author on ‘
Mutant zebrafish lacking slc25a22a show spontaneous seizures and respond to the anti-seizure medication valproic acid’, published in DMM. So-Hyun is a research professor in the lab of Seok-Yong Choi at Chonnam National University Medical School, Hwasun, Republic of Korea, investigating the molecular pathogenesis of epilepsy using a zebrafish model.

## Linked entities

- **Genes:** slc25a22a (solute carrier family 25 member 22a) [NCBI Gene 571044]
- **Chemicals:** valproic acid (PubChem CID 3121)
- **Diseases:** epilepsy (MONDO:0005027)
- **Species:** Danio rerio (taxon 7955)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12208192/full.md

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Source: https://tomesphere.com/paper/PMC12208192