# Evidence for fomite transmission of SARS‐CoV‐2 Omicron variant in a mouse model

**Authors:** Sidi Yang, Liu Cao, Kun Li, Tiefeng Xu, Zixiao Yang, Yanxi Ji, Lihong Liu, Birong Zheng, Changwen Ke, Xiaofang Peng, Hong Peng, Deyin Guo, Chun‐Mei Li

PMC · DOI: 10.1002/mlf2.70022 · 2025-06-24

## TL;DR

This study shows that SARS-CoV-2 Omicron can spread via contaminated surfaces in mice, but the risk is low with good hygiene.

## Contribution

The study experimentally demonstrates fomite transmission of SARS-CoV-2 Omicron in a mouse model.

## Key findings

- Fomite transmission of SARS-CoV-2 Omicron occurred in some cases in the mouse model.
- The risk of fomite transmission is low in natural settings with proper hygiene.
- The findings could inform public health strategies for controlling the pandemic.

## Abstract

Throughout the COVID‐19 pandemic, the risk of fomite‐based transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has not been systematically investigated. In this study, we employed the K18‐hACE2 mouse infection model to experimentally assess the relative contribution of fomite transmission. Our findings indicate that while fomite transmission can occur in certain cases, the risk of fomite transmission in natural settings may be relatively low when appropriate hygiene practices are followed. These results may help optimize public health measures for more effective control of the COVID‐19 pandemic.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)
- **Species:** Mus musculus (taxon 10090)

## Full-text entities

- **Genes:** KRT18 (keratin 18) [NCBI Gene 3875] {aka CK-18, CYK18, K18}
- **Diseases:** infection (MESH:D007239), COVID-19 (MESH:D000086382)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12207898/full.md

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Source: https://tomesphere.com/paper/PMC12207898