# Front Cover

## TL;DR

This study explores how oligodendrocytes and neurons interact in cognitive decline after high-altitude cerebral edema using advanced sequencing techniques.

## Contribution

The paper reveals a novel mechanism of cell interaction linked to cognitive decline following high-altitude cerebral edema.

## Key findings

- Single-cell RNA sequencing identified distinct gene expression patterns in oligodendrocytes and neurons.
- Spatial transcriptomics showed altered cell communication pathways in affected brain regions.
- The findings suggest a new therapeutic target for cognitive impairments after cerebral edema.

## Abstract

The cover image is based on the article Single‐Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte–Neuron Interaction in Cognitive Decline After High‐Altitude Cerebral Edema by Wenying Lv et al., https://doi.org/10.1111/cns.70485.