# Unmasking Pheochromocytoma, a Rare Case of Diabetic Ketoacidosis as the First Clue

**Authors:** Dina Saba, Mehreen Malik Khan, Joseph An Vu

PMC · DOI: 10.1210/jcemcr/luaf135 · 2025-06-24

## TL;DR

A rare case shows that diabetic ketoacidosis can be the first sign of pheochromocytoma, a tumor that was later treated successfully.

## Contribution

This case highlights a novel and unusual presentation of pheochromocytoma as the initial symptom of diabetic ketoacidosis.

## Key findings

- A 62-year-old woman presented with diabetic ketoacidosis and was found to have bilateral adrenal masses.
- Biochemical analysis confirmed pheochromocytoma, and adrenalectomy resolved her diabetes.
- This case suggests that DKA can be an initial clue for pheochromocytoma.

## Abstract

We report the case of a 62-year-old woman with nausea, vomiting, abdominal pain, polyuria, and polydipsia presenting to the emergency room and found to have new-onset diabetes with diabetic ketoacidosis (DKA). Incidentally discovered bilateral adrenal masses found during evaluation for possible abdominal abscess prompted further investigation, and pheochromocytoma was confirmed through biochemical analysis. She was treated with adrenalectomy, resulting in resolution of diabetes. This case demonstrates a unique presentation of pheochromocytoma with DKA.

## Linked entities

- **Diseases:** diabetic ketoacidosis (MONDO:0012819), pheochromocytoma (MONDO:0004974)

## Full-text entities

- **Diseases:** adrenal masses (MESH:C536030), Pheochromocytoma (MESH:D010673), vomiting (MESH:D014839), nausea (MESH:D009325), abdominal abscess (MESH:D018784), polydipsia (MESH:D059606), diabetes (MESH:D003920), abdominal pain (MESH:D015746), DKA (MESH:D016883), polyuria (MESH:D011141)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12206096/full.md

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Source: https://tomesphere.com/paper/PMC12206096