# Cardiovascular adverse events in patients with lung cancer treated with immune checkpoint inhibitors: a nationwide database study

## TL;DR

This study found that lung cancer patients treated with immune checkpoint inhibitors had a higher risk of major cardiovascular events, especially myocarditis and pericarditis, compared to those receiving traditional chemotherapy.

## Contribution

The study identifies specific cardiovascular risks and risk factors associated with immune checkpoint inhibitors in lung cancer patients using a nationwide database.

## Key findings

- ICI-treated patients had a 1.98 times higher risk of MACEs compared to non-ICI chemotherapy patients.
- Myocarditis and pericarditis occurred significantly more in ICI-treated patients.
- Prior heart failure and chronic renal failure were significant risk factors for MACEs in ICI-treated patients.

## Abstract

Large, diverse cohort studies are essential for determining the incidence and risk factors of major adverse cardiovascular events (MACEs) associated with immune checkpoint inhibitors (ICIs). This study aimed to (1) compare the incidence of MACEs in primary lung cancer patients receiving ICIs versus those receiving non-ICI chemotherapy, and (2) identify risk factors for MACEs in ICI-treated patients.

We performed a retrospective analysis of primary lung cancer patients using a nationwide Japanese database. Patients were stratified by their use of ICIs, and after propensity score matching, outcomes were evaluated over 180 days.

The study included 743 propensity-matched patients in each cohort. The median follow-up period was 329 days (interquartile range, 147-625). At 180 days, 4.0% of ICI-treated patients experienced MACEs, significantly higher than those treated with non-ICI chemotherapy (hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.07-3.69; P-value = .030). Among MACEs, myocarditis and pericarditis occurred significantly more frequently in patients receiving ICI treatment than in those receiving non-ICI chemotherapy (P-value = .048 for both outcomes). No significant differences were observed in other MACE components. In multivariable analysis, chronic renal failure (HR, 2.16; 95% CI, 1.05-4.46; P-value = 0.038) and prior heart failure (HR, 3.08; 95% CI, 1.86-5.11; P-value < 0.001) were significant risk factors for MACEs.

ICI treatment was associated with more frequent MACEs, primarily due to myocarditis and pericarditis. Additionally, prior heart failure and chronic renal failure were key risk factors for MACEs.

UMIN000051698

Graphical Abstract