The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review

TL;DR

This umbrella review summarizes maternal risk factors during pregnancy that are associated with intrauterine growth retardation.

Contribution

The study provides the first umbrella review of maternal factors linked to intrauterine growth retardation.

Findings

Placenta previa, placenta abruption, epilepsy in pregnancy, and HCV infection show suggestive evidence for IUGR.

Celiac disease and Mullerian anomaly are associated with IUGR with weak evidence.

Abstract

There is no umbrella review on maternal risk factors associated with intrauterine growth retardation (IUGR). Therefore, we assessed an umbrella review on maternal risk factors during pregnancy for IUGR.

We searched three prominent international databases: PubMed, Scopus, Web of Science, and Cochrane Library. We focused on meta-analyses that examined maternal factors during pregnancy associated with IUGR. The comparison was based on the odds ratio (OR) or related risk ratios reported in the included studies, heterogeneity I
2, 95% prediction interval, small-study effects, excess significance biases, and sensitive analysis.

Four risk factors for IUGR include placenta previa with an OR of 1.19, placenta abruption with an OR of 2.06, epilepsy in pregnancy with an OR of 1.28, and hepatitis C virus (HCV) infection with an OR of 1.53 were categorized as having suggestive evidence (Class III). Celiac disease with an OR of 2.48 and mullerian anomaly with an OR of 1.93 were considered risk factors with weak evidence (Class IV).

Four risk factors for IUGR including placenta previa, placenta abruption, epilepsy in pregnancy, and HCV infection were categorized as having suggestive evidence (Class III). Celiac disease and Mullerian anomaly were considered risk factors with weak evidence (Class IV).

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