# The ability of ozone to counteract multidrug-resistant bacteria if used as an adjunct therapy: a bioinformatic modelling

## TL;DR

This study explores ozone as a potential adjunct therapy to combat multidrug-resistant bacteria using bioinformatic modeling.

## Contribution

The paper introduces a novel bioinformatic approach to model ozone's effects on bacteria and immune responses.

## Key findings

- Ozone therapy shows bactericidal effects and immune modulation through 4-hydroxynonenal production.
- Ozone-induced adaptive chaos may improve immune resilience and bacterial clearance compared to antibiotics alone.
- Theoretical results highlight the need for experimental validation due to ozone's short half-life.

## Abstract

Multidrug-resistant (MDR) bacteria pose a growing threat to global health, prompting exploration of alternative therapies. This study uses bioinformatic modelling to assess ozone therapy as an adjunct treatment, analysing both linear and non-linear (chaotic) frameworks. Results suggest that ozone exerts bactericidal effects and modulates immune responses, partly through the production of 4-hydroxynonenal. Simulations indicate that ozone-induced adaptive chaos may enhance immune resilience and accelerate bacterial clearance compared to antibiotics alone. However, the findings are theoretical, and the short half-life of ozone limits direct impact, emphasizing the need for experimental validation. Ozone therapy shows promise, but its role in adaptive chaos requires further study to determine its clinical viability, despite a large number of reports showing an undisputable action of medical ozone against MDR bacteria.