# The Effectiveness of Direct Oral Anticoagulation in the Treatment of Left Ventricular Thrombus in Noncompaction Cardiomyopathy: A Case Report

**Authors:** Ossama Maadarani, Leila Bigdelu, Harikrishna Rajendran, Zouhair Bitar

PMC · DOI: 10.1002/ccr3.70583 · 2025-06-27

## TL;DR

This case report shows that direct oral anticoagulants can effectively treat a heart condition in a patient with noncompaction cardiomyopathy.

## Contribution

This is the second reported case of successful LVT treatment in NCCM using DOACs.

## Key findings

- DOACs led to complete resolution of left ventricular thrombus in a noncompaction cardiomyopathy patient.
- This case supports the potential use of DOACs for treating LVT in NCCM.
- There is limited evidence on DOACs for this specific condition.

## Abstract

The use of direct oral anticoagulants (DOACs) in the treatment of left ventricular thrombus (LVT) associated with specific types of cardiomyopathy like noncompaction cardiomyopathy (NCCM) is not established. We report a case of LVT in an NCCM patient treated with DOAC with complete resolution. To the best of our knowledge, this is the second case of successful treatment of LVT related to NCCM with DOACs.

## Linked entities

- **Diseases:** noncompaction cardiomyopathy (MONDO:0005418)

## Full-text entities

- **Diseases:** NCCM (MESH:C565277), LVT (MESH:D013927), cardiomyopathy (MESH:D009202)
- **Chemicals:** DOAC (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12204809/full.md

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Source: https://tomesphere.com/paper/PMC12204809