Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries

TL;DR

This study shows that casticin can reduce ovarian and lung damage caused by ovarian torsion in rats, suggesting it may be a promising treatment for this gynecological emergency.

Contribution

The study demonstrates casticin's novel therapeutic potential in mitigating ovarian torsion/detorsion-induced injuries.

Findings

Casticin reduced oxidative stress and inflammation markers in ovarian and lung tissues.

Casticin improved antioxidant defense in tissues affected by torsion/detorsion.

Casticin administration attenuated tissue damage in a rat model of ovarian torsion.

Abstract

Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion (T/D) can lead to severe complications, including infertility, if not promptly addressed. This study aimed to investigate the therapeutic effects of casticin (CAST) on ovarian and lung tissue injuries induced by a bilateral ovarian T/D model in rats.

Experimental animals were randomly allocated into groups of sham, T/D, CAST 5 mg/kg, and CAST 10 mg/kg. Ovarian and lung tissues were subjected to biochemical, histopathological, and immunohistochemical analyses.

In the T/D group, markers of oxidative stress and inflammation, including myeloperoxidase (MPO) activity, malondialdehyde (MDA), oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2’ deoxyguanosine (8-OHdG), were significantly elevated (P<0.05). Conversely, superoxide dismutase (SOD) activity and total antioxidant status (TAS) levels were notably decreased (P<0.05). CAST administration significantly attenuated tissue damage by reducing oxidative stress and inflammatory markers while enhancing antioxidant defense (P<0.05).

CAST demonstrated a therapeutic effect against ovarian and lung tissue damage induced by T/D, suggesting that it may serve as a potential therapeutic agent for treating ovarian T/D-related injuries. These findings underscore the potential of CAST in clinical settings, particularly as a novel intervention to mitigate complications associated with I/R injuries in gynecological emergencies.

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