# Gastrointestinal Complications of Systemic Sclerosis: A Case Report

**Authors:** Mason Arbabi, Bella Garg, Saviz Saghari, Paryus Patel

PMC · DOI: 10.7759/cureus.86844 · 2025-06-27

## TL;DR

This case report describes a patient with systemic sclerosis experiencing severe gastrointestinal complications that led to a decision for hospice care.

## Contribution

The report provides a detailed clinical case highlighting the severe gastrointestinal complications in systemic sclerosis.

## Key findings

- Severe gastrointestinal involvement in systemic sclerosis can lead to significant morbidity and mortality.
- GI dysfunction in SSc impacts quality of life and may necessitate hospice care for comfort-focused treatment.

## Abstract

Systemic sclerosis (SSc) is a rare, chronic systemic rheumatic disease. Gastrointestinal (GI) involvement is highly prevalent in SSc and any part of the GI tract may be affected. This can range from mild symptoms like heartburn and dysphagia to severe issues like abdominal distention, malnutrition, and fecal incontinence. In SSc patients, GI tract dysfunction significantly impacts the quality of life and is a major contributor to both morbidity and mortality. This case report highlights an 80-year-old female patient with SSc/CREST (Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasia) syndrome experiencing severe GI involvement who presented to the emergency department with hypoxic respiratory failure and acute kidney injury. The patient and her family finally made the decision to transition to inpatient hospice care, focusing on comfort and dignity, leading to the patient's peaceful passing.

## Linked entities

- **Diseases:** Systemic sclerosis (MONDO:0005100), CREST syndrome (MONDO:0019563), acute kidney injury (MONDO:0002492)

## Full-text entities

- **Diseases:** Calcinosis (MESH:D002114), fecal incontinence (MESH:D005242), GI tract dysfunction (MESH:D005770), Sclerodactyly (MESH:C535336), abdominal distention (MESH:D000007), Esophageal dysfunction (MESH:D004935), CREST (MESH:D017675), acute kidney injury (MESH:D058186), dysphagia (MESH:D003680), hypoxic (MESH:D002534), Raynaud's phenomenon (MESH:D011928), SSc (MESH:D012595), Telangiectasia (MESH:D013684), GI involvement (MESH:D005767), systemic rheumatic disease (MESH:D012216), respiratory failure (MESH:D012131), heartburn (MESH:D006356), malnutrition (MESH:D044342)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12203754/full.md

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Source: https://tomesphere.com/paper/PMC12203754