Optical theranostics in ischemic heart disease: from molecular insights to clinical translation
Yangjie Xiao, Jing Zhang, Lu Sun, Ke Wang, Yan Chen, Qiaojin Zheng, Ying Li
TL;DR
Optical theranostics combine imaging and therapy using light to improve diagnosis and treatment of heart disease, offering new ways to manage this major health issue.
Contribution
This review provides a comprehensive analysis of optical theranostics for ischemic heart disease, highlighting their potential for clinical translation.
Findings
Optical imaging modalities like OCT and photoacoustic imaging offer high-resolution visualization of coronary anatomy and molecular biomarkers.
Photodynamic and photothermal therapies show therapeutic potential in preclinical studies for ischemic heart disease.
Integrated theranostic platforms enable closed-loop workflows that use imaging to guide therapy and monitor response in real time.
Abstract
Accurate risk stratification of ischemic heart disease (IHD) remains pivotal for mitigating associated global health burdens. Optical theranostics, combining imaging and therapeutic capabilities through light-based technologies, has emerged as a transformative strategy for IHD management. Advanced modalities mainly including optical coherence tomography, near-infrared fluorescence imaging, and photoacoustic imaging enable high-resolution visualization of coronary anatomy, myocardial perfusion, and molecular biomarkers. These modalities complement traditional cardiovascular imaging by providing real-time functional and molecular data with enhanced spatial resolution. Concurrently, phototherapy strategies such as image-guided photodynamic and photothermal therapies show therapeutic potential in preclinical studies. Integrated theranostic platforms now operationalize closed-loop workflows,…
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Taxonomy
TopicsPhotoacoustic and Ultrasonic Imaging · Photoreceptor and optogenetics research · Advanced Fluorescence Microscopy Techniques