# Circadian metabolism in myeloid cells

## TL;DR

This paper explores how circadian rhythms regulate metabolism in myeloid cells, affecting immune functions like inflammation and tissue repair.

## Contribution

The paper reviews the novel interplay between circadian clocks, metabolism, and myeloid immunity, highlighting therapeutic opportunities.

## Key findings

- Myeloid cells have intrinsic circadian clocks that regulate their behavior and function.
- Circadian control of metabolism influences inflammatory and tissue-repair roles in myeloid subsets.
- Mitochondrial dynamics, under circadian regulation, impact antigen presentation and immune responses.

## Abstract

Circadian rhythms are fundamental regulators of physiological processes, including immune function. Recent insights uncover that not only lymphocytes but also myeloid cells possess intrinsic circadian clocks that govern their behavior and function. Emerging evidence highlights how circadian regulation of metabolism critically shapes the inflammatory and tissue-repair functions of myeloid subsets. Furthermore, mitochondrial dynamics, a key metabolic feature, are under circadian control and influence antigen presentation and effector functions. Here, we review the interplay between circadian clocks, metabolism, and myeloid immunity, discussing their therapeutic opportunities for optimizing vaccination, infection management, and immunotherapy.