# Self-reported health and depression among EIRA cohort: a moderated mediation model of sex and perceived social support

## TL;DR

This study explores how perceived social support affects the relationship between depression and self-reported health, with a focus on gender differences in a primary care setting.

## Contribution

The study introduces a moderated mediation model to examine gender-specific effects of social support on health and depression after a multiple-risk intervention.

## Key findings

- Men initially reported higher social support and self-perceived health than women.
- Post-intervention, women showed greater increases in social support compared to men.
- Lower depression scores were associated with higher social support for both genders after the intervention.

## Abstract

The positive relationship between health and good perceived social support has been widely demonstrated in the scientific literature. It is known that having a good social support influences the proper maintenance of health even as a protective factor, besides being a good predictor in the recovery of health during a disease process, influencing differently men and women.

This project aims to study the moderating effects of perceived social support in the relationship between depression and self-perceived health according to gender, after a complex multiple-risk intervention was carried out in patients of primary health care with low social support.

A cluster randomized clinical trial was developed in the subgroup of patients included in phase 3 of the EIRA project. CONSORT recommendations were followed to present the results. To determine the mediating effect between social support and self-perceived health, three regression analyses were carried out using the procedure designed by Hayes through the PROCESS macro for SPSS.

3,062 people (54.9% women) participated in the study. Men reported experiencing more social support and self-perceived health (p < 0.001) than women at the beginning of the study, but women reported higher social support at post-intervention. Moderation analyses showed that, post-intervention, those women (bsimple = −2.9867, p < 0.001) and males (bsimple = −1.4337, p < 0.001) who scored lower in depression reported higher social support.

In primary care, it is necessary to encourage intervention strategies that promote social networks as a key element of positive action aimed at maintaining and improving the population’s health, especially in adults and more specifically in women.

ClinicalTrials.gov, identifier NCT03136211.