# Atypical anti-glomerular basement membrane disease: two case reports

## TL;DR

This paper reports two unusual cases of anti-GBM disease with atypical features and highlights the need for tailored treatment approaches.

## Contribution

The paper presents two novel atypical anti-GBM disease cases with negative antibody tests and minimal kidney damage.

## Key findings

- Both cases showed negative anti-GBM antibody tests but still exhibited disease features.
- High-dose steroids led to positive outcomes despite the absence of standard treatment guidelines.
- The cases suggest a broader spectrum of anti-GBM-related conditions than previously recognized.

## Abstract

Atypical Anti-Glomerular Basement Membrane (anti-GBM) Disease, a variant of the rare autoimmune disorder Goodpasture’s disease, presents unique challenges in diagnosis and management. This article presents two cases of atypical anti-GBM disease characterized by negative serological tests for anti-GBM antibodies, minimal renal impact on kidney biopsy, and absence of pulmonary involvement. These cases underscore the evolving spectrum of renal anti-GBM-related conditions and the need for a nuanced approach to diagnosis and treatment. Treatment with high-dose steroids resulted in favorable outcomes in both cases, highlighting the importance of individualized management strategies, especially given the absence of standardized recommendations for this uncommon presentation. Further research is warranted to elucidate the pathophysiology and optimal management of atypical anti-GBM disease.