# Chronic leg ulcers in a patient with Hyperoxaluria type 1: a rare and challenging diagnosis

## TL;DR

A 29-year-old woman with Hyperoxaluria type 1 and kidney failure developed severe leg ulcers due to calciphylaxis, a rare condition that was successfully managed with specialized treatments.

## Contribution

This case highlights the rare and challenging co-occurrence of calciphylaxis and Hyperoxaluria type 1, offering insights into its management.

## Key findings

- The patient's leg ulcers were caused by calciphylaxis, not cutaneous oxalosis as initially suspected.
- Treatment included medical therapy, high-flow oxygen, advanced wound care, and dialysis with low-calcium dialysate.
- The case demonstrates successful management of a rare combination of hyperoxaluria and calciphylaxis.

## Abstract

Calciphylaxis is an uncommon yet highly severe condition characterized by systemic medial calcification of arterioles, leading to ischemia and subsequent tissue necrosis. we report the case of a 29 year-old female suffering from primary hyperoxaluria type 1 and end-stage renal disease, Developed multiple painful ulcerations on her legs, initially believed to be due to cutaneous oxalosis. However, pathology findings revealed calciphylaxis. The association calciphylaxis and hyperoxaluria is rare, making this case unique. and she was treated with medical therapy, high-flow oxygen therapy and advanced wound dressings to facilitate granulation tissue formation and optimize ulcer healing, and daily hemodialysis with a low-calcium dialysate.