# Analysis of the Correlation Between MDS Inflammatory Indicators and Clinical Characteristics: A Comprehensive Analysis

## TL;DR

This study explores how inflammatory markers like NLR, MLR, and PLR are linked to clinical features in myelodysplastic syndrome (MDS), offering insights for diagnosis and treatment.

## Contribution

The study identifies specific correlations between MDS inflammatory indicators and clinical parameters, offering new insights for early diagnosis and treatment strategies.

## Key findings

- NLR and PLR showed high diagnostic specificity for MDS with AUC values of 0.9169 and 0.8312.
- MLR correlated strongly with initial white blood cell count (r = 0.661), and NLR with lactate dehydrogenase levels (r = 0.313).
- Patients with low PLR had higher survival times compared to those with high PLR (p = 0.007).

## Abstract

Objective: This study aims to investigate the correlations among the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) at the initial diagnosis of myelodysplastic syndrome (MDS) and the clinical characteristics of patients. It explores the correlation between MDS and inflammatory markers, providing a basis for early assessment of treatment efficacy, diagnosis, and guiding personalized treatment.

Methods: Analyzing the bone marrow smears and flow cytometry immunophenotyping of 70 MDS patients. Conducting a comparative analysis of the multi-parameter linear correlation between the clinical characteristics of MDS patients and inflammatory markers, comparing the differences in inflammatory markers between MDS patients and the control group. Additionally, investigating the differential correlation analysis between different primitive cell ratios, different MDS types, different immunophenotypic characteristics, different morphological features, and inflammatory markers.

Results: Comparative analysis between MDS and the control group revealed that NLR and PLR have good diagnostic specificity (area under the curve [AUC] = 0.9169, 0.8312). When comparing the clinical characteristics of MDS patients, MLR showed a strong correlation with the total white blood cell count at the initial diagnosis (r = 0.661, p = 0.0004), while NLR demonstrated a correlation with lactate dehydrogenase (LDH; r = 0.313, p = 0.037). In different WHO-classified MDS groups, there are significant differences in the comparison of three groups of inflammatory markers between the groups. The MDS group with specific immunophenotypic characteristics displayed significant differences in PLR compared to the group without specific immunophenotypic characteristics. Additionally, CD34 proportion exhibited a negative correlation with NLR index (r = −0.296, p = 0.0129). And patients with low PLR index have a higher survival time than those with high PLR index (p = 0.007).

Conclusion: Inflammatory markers are correlated with the clinical characteristics of MDS, providing not only auxiliary evidence for the clinical diagnosis of MDS but also showing differences in inflammatory markers based on different tumor burdens in MDS. This serves as a reference for the treatment strategy of inhibiting the progression of MDS to acute leukemia by reversing the inflammatory trend.