# Aortic Non-coronary Cusp Perforation Following Methicillin-Sensitive Staphylococcus aureus (MSSA) Endocarditis

**Authors:** Rea Isaac, Dhara Rana, Aobo Li, Vakula Atthota, Benjamin Silverman

PMC · DOI: 10.7759/cureus.84897 · Cureus · 2025-05-27

## TL;DR

A rare case of aortic valve damage occurred after a patient recovered from a bacterial heart infection.

## Contribution

Highlights a rare late complication of MSSA endocarditis: isolated non-coronary cusp perforation.

## Key findings

- Patient developed severe aortic insufficiency after MSSA endocarditis recovery.
- Perforation occurred in the non-coronary cusp of the aortic valve.
- Emphasizes the need for long-term monitoring after endocarditis.

## Abstract

Isolated perforation of the aortic valve’s noncoronary cusp (NCC) is an exceptionally rare but serious complication following bacterial endocarditis. Here we present a unique case of a 62-year-old male who developed an isolated NCC perforation after recovering from Methicillin-sensitive Staphylococcus aureus (MSSA) endocarditis. Despite successful antibiotic therapy, the patient experienced progressive cardiac symptoms, ultimately leading to the discovery of severe aortic insufficiency due to NCC perforation. This case underscores the importance of vigilant follow-up and the potential for late-onset complications in patients with a history of endocarditis.

## Linked entities

- **Diseases:** endocarditis (MONDO:0005025), aortic insufficiency (MONDO:0005648)

## Full-text entities

- **Diseases:** Endocarditis (MESH:D004696), bacterial endocarditis (MESH:D004697), aortic insufficiency (MESH:D001022), cardiac (MESH:D006331), Perforation (MESH:D057112)
- **Chemicals:** Methicillin (MESH:D008712)
- **Species:** Staphylococcus aureus (species) [taxon 1280], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12202057/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12202057/full.md

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Source: https://tomesphere.com/paper/PMC12202057