Locally Advanced Cervical Cancer in a Patient with Epidermolysis Bullosa Treated with Concurrent Chemoradiotherapy and Electronic Brachytherapy
Desislava Hitova-Topkarova, Virginia Payakova, Angel Yordanov, Desislava Kostova-Lefterova, Elitsa Encheva
TL;DR
A patient with a rare skin condition and cervical cancer was successfully treated with a combination of radiotherapy, chemotherapy, and electronic brachytherapy without worsening her skin condition.
Contribution
This is the first report of combined chemoradiotherapy and electronic brachytherapy for cervical cancer in a patient with epidermolysis bullosa.
Findings
The treatment was well-tolerated with no grade 2 or higher adverse events during follow-up.
Electronic brachytherapy delivered targeted doses without increasing skin toxicity.
The institutional protocol ensured low doses to organs at risk and reproducibility.
Abstract
Background and Clinical Significance: The purpose of this report is to investigate the feasibility of combined modality treatment in a case of locally advanced cervical cancer in a patient with inherited epidermolysis bullosa as well as to suggest a protocol for cervical electronic brachytherapy. Case Description: The patient was treated with image-guided external beam radiotherapy and concomitant chemotherapy to a dose of 45 Gy in 25 fractions with a simultaneously integrated boost of 55 Gy in involved lymph nodes. The maximal skin dose was 34.09 Gy. Intracavitary electronic brachytherapy was applied to the uterine cervix in 4 fractions of 7 Gy and contributed no dose to the skin. Discussion: The treatment was tolerated well with no early toxicity. During the 3-month period of follow-up, no adverse events of grade 2 or higher were detected, and no exacerbation of skin lesions was…
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Taxonomy
TopicsSkin and Cellular Biology Research · Cutaneous lymphoproliferative disorders research · Cancer and Skin Lesions