Bowel function after surgery in male children with complicated anorectal malformations

TL;DR

This study examines long-term bowel function in boys with complicated anorectal malformations after surgery, identifying factors that influence outcomes.

Contribution

The study identifies spinal cord anomalies and long operation intervals as risk factors for poor bowel function in male children with complicated anorectal malformations.

Findings

Spinal cord anomalies significantly worsen postoperative bowel function (OR = 4.651, p = 0.032).

Longer intervals between the first and third operations increase the risk of poor outcomes (OR = 3.808, p = 0.039).

Perianal muscle development is significantly associated with bowel function (p = 0.023).

Abstract

Some children may experience defecation dysfunction following surgery for anorectal malformations. This study evaluated the long-term functional outcomes and influencing factors in male children with complicated anorectal malformations (ARMs).

We retrospectively analyzed the clinical data of male children with complicated ARMs who underwent staged surgeries in our hospital from 2013 to 2016. Data collected included ARM type, perianal muscle development, anorectal manometry findings, lumbosacral MRI findings and the intervals between the first and third operation. Bowel function after the operation was assessed by questionnaire (modified Rintala score). Logistic regression analysis was used to analyze the influencing factors of prognosis.

Fifty-eight children were included in this study, with a median age at PSARP of 6.7 months. Bowel function did not differ based on anorectal malformations subtype (p = 0.212). Perianal muscle development was significantly associated with bowel function (p = 0.023, rs = 0.297). Fifty-one children received anorectal manometry, which showed no significant differences in anal resting pressure (ARP) among the different bowel function groups(p = 0.666). Rectoanal inhibitory reflex (RAIR) was present in 3/12 (25%), 10/36 (27.8%), and 1/3 (33.3%) children in the normal, good, and fair groups, respectively (p = 0.781). Bowel function was significantly worse in children with spinal cord anomalies than in children with normal spinal cord (OR = 4.651, p = 0.032). Stooling level worsened with increasing intervals between the first and third operation (OR = 3.808, p = 0.039).

The incidence of spinal cord abnormalities in male children with complicated ARMs was high. Spinal cord anomalies and long intervals of the staging operation increased the risk of poor postoperative outcomes.

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