An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action
Patrícia Mariano Cruz Pereira, Andréa de Cássia Rodrigues Silva, Karen Miyuki Asano, Adriana da Costa Neves, Juliana Mozer Sciani, Daniel Carvalho Pimenta, Hugo Vigerelli
TL;DR
This study explores how the compound bufotenine, derived from a Brazilian plant, may help fight rabies by boosting the immune response and reducing brain damage in mice.
Contribution
The study provides new insights into the antiviral and immunomodulatory effects of bufotenine in a murine rabies model.
Findings
Bufotenine delayed the manifestation of rabies symptoms in mice.
It reduced mononuclear cell inflammatory infiltrate in the meninx region of the CNS.
Bufotenine contributed to reduced neuronal degeneration in infected mice.
Abstract
Molecules from animals or plant species have been investigated with the aim of treating diseases of epidemiological importance, such as rabies, which is a viral, acute, and infectious disease with approximately 100% lethality. Rabies has been one of the main causes of death in humans concerning infectious diseases. This work investigated the action and preliminary mechanisms of the alkaloid bufotenine in an in vivo model with the rabies virus. A wild-type virus was titrated and injected into mice for the determination of DL50 in the presence or absence of bufotenine. The results reveal that bufotenine has possible action in modulating the immune response of the studied host, suggesting interference in delaying symptom manifestation. Regarding the histological analysis of the CNS of the animals, bufotenine possibly prevented the presence of mononuclear cell inflammatory infiltrate in the…
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Taxonomy
TopicsRabies epidemiology and control · Venomous Animal Envenomation and Studies · Antimicrobial Peptides and Activities