# How Do Patients' Fear Prediction and Fear Experience Impact Exposure-Based Therapy for Panic Disorder With Agoraphobia? A Comprehensive Analysis of Fear Prediction

**Authors:** Marina Hilleke, Thomas Lang, Sylvia Helbig-Lang, Georg W. Alpers, Volker Arolt, Jürgen Deckert, Thomas Fydrich, Alfons O. Hamm, Tilo Kircher, Jan Richter, Andreas Ströhle, Hans-Ulrich Wittchen, Alexander L. Gerlach

PMC · DOI: 10.1155/da/6963860 · 2025-06-18

## TL;DR

This study explores how patients' predicted fear versus actual fear during exposure therapy affects treatment outcomes for panic disorder with agoraphobia.

## Contribution

The study introduces a novel analysis of fear prediction accuracy and its impact on exposure therapy outcomes using Rachman's model.

## Key findings

- Patients tend to overpredict fear during exposure therapy.
- Reduction in expected fear over time strongly predicts treatment success.
- Fear prediction accuracy remains stable despite decreases in both expected and experienced fear.

## Abstract

Expectancy violation has been proposed as a potential core mechanism of action in psychotherapy, particularly in exposure therapy for anxiety disorders. However, various relevant expectations have been discussed, and empirical studies examining their significance are still scarce. This study aimed to investigate one specific form of expectancy violation, based on Rachman's (1994) match-mismatch model, specifically by comparing expected and experienced fear and examining their relationship to safety behaviour during exposure in vivo in 268 patients meeting DSM-IV criteria for panic disorder with agoraphobia. Participants underwent exposure to a highly controlled manual-based cognitive behaviour therapy in a randomised multicenter psychotherapy study. Participants tended to overpredict fear during exposure. Both expected and experienced fear significantly decreased over the course of repeated exposure exercises, while prediction (in)accuracy (difference between expected and experienced fear) remained stable. The decrease in expected fear over time was a strong predictor of treatment outcomes for the Bodily Sensations Questionnaire (BSQ) and Panic and Agoraphobia Scale (PAS) at post. Even more, the reduction in expected fear was a significant predictor of treatment success across all outcome measures in the follow-up assessment. These findings suggest that violating excessive fear expectancies is not a necessary condition for symptom reduction during exposure therapy.

## Linked entities

- **Diseases:** panic disorder (MONDO:0005383), agoraphobia (MONDO:0003709)

## Full-text entities

- **Diseases:** anxiety disorders (MESH:D001008), Agoraphobia (MESH:D000379), Panic Disorder (MESH:D016584)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12197478/full.md

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Source: https://tomesphere.com/paper/PMC12197478