# Preparation of a Biomedical Scaffold from High-Molecular-Weight Poly-DL-Lactic Acid Synthesized via Ring-Opening Polymerization

## TL;DR

This study creates a biomedical scaffold from high-molecular-weight poly-DL-lactic acid using ring-opening polymerization, showing promising properties for tissue engineering.

## Contribution

A novel method for synthesizing high-molecular-weight PDLLA with optimized parameters for biomedical scaffold fabrication.

## Key findings

- The highest molecular weight PDLLA was achieved with 6 h oligomerization, 4 h ROP, and 1% catalyst.
- The scaffold exhibited 71.6% porosity, 85.97° contact angle, and a compressive strength of 4.24 MPa.
- Thermal stability was maintained below 40 °C, and the polymerization followed a first-order kinetic model.

## Abstract

In this study, poly-DL-lactic acid (PDLLA) was synthesized via ring-opening polymerization (ROP) to develop a biomedical scaffold for tissue engineering. A rotary evaporator with a two-stage vacuum pump under an inert atmosphere and constant stirring was used. A factorial design with three factors (oligomerization time, ROP time, and catalyst concentration) at two levels was applied. Polymers were characterized by FTIR, capillary viscometry, 1H-NMR, DSC, and TGA. The kinetic study revealed a first-order model, indicating that the polymerization rate depends linearly on monomer concentration. The activation energy (70.5 kJ/mol) suggests a moderate energy requirement, consistent with ring-opening polymerization, while the high pre-exponential factor (6.93 × 106 min−1) reflects a significant frequency of molecular collisions. The scaffold was fabricated via extrusion and 3D printing, and its morphology, porosity, mechanical properties, and contact angle were studied. The highest molecular weight PDLLA was obtained with 6 h of oligomerization, 4 h of ROP, and 1% catalyst concentration. The samples exhibited thermal stability below 40 °C, while the scaffold reached 71.6% porosity, an 85.97° contact angle, and a compressive strength of 4.24 MPa with an elastic modulus of 51.7 MPa. These findings demonstrate the scaffold’s potential for biomedical applications.