# Exploring Oral Polymorphous Adenocarcinoma: Clinical Characteristics, Diagnosis, and Treatment Outcomes. A Case Report

## TL;DR

This case report describes a rare oral cancer in a 61-year-old woman, highlighting its diagnosis and treatment through surgery.

## Contribution

The report provides a clinical case of polymorphous adenocarcinoma in the oral palate with specific immunohistochemical findings aiding diagnosis.

## Key findings

- The tumor was localized in the palate and showed an immunophenotype of p63+/p40-.
- Surgical excision is emphasized as the primary treatment to achieve optimal outcomes.
- Early and accurate diagnosis is crucial to avoid misdiagnosis as a benign tumor.

## Abstract

Background and clinical significance: Polymorphous adenocarcinoma of the oral cavity is predominantly located in the palate. It is characterized by a slow rate of growth and thus may be misdiagnosed as a benign tumor. Its histology is intricate with other salivary malignancies, thus necessitating specific immunohistochemical stains. Our case report illustrates an adenocarcinoma localized in the palate of a 61-year-old female patient. Case presentation: The patient came to the postgraduate clinic of Oral Medicine and Pathology, Department of Oral Medicine and Pathology, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece and provided written informed consent for the subsequent examination. The patient complained about the presence of a mass on the palate, which was otherwise asymptomatic, without being able to pinpoint when the tumor initially emerged. The lesion was biopsied and the histology suggested the immunophenotype p63+/p40- which constitutes an important diagnostic clue for polymorphous adenocarcinoma. The patient was referred to the Department of Oral and Maxillofacial Surgery. Conclusions: The standard therapeutic approach primarily involves surgical excision. The goal is to achieve optimal patient outcome while minimizing unnecessary morbidity. As surgical techniques and understanding of the disease continue to advance, it is crucial for healthcare providers to stay informed and integrate these developments into practice to improve treatment outcomes for patients.