# Neurodevelopmental Outcomes in Children with Neonatal Parechovirus CNS Infections

## TL;DR

This study examines the long-term neurodevelopmental outcomes of infants infected with Parechovirus A (PeV-A) encephalitis, finding no significant complications at 24 months.

## Contribution

The study provides new evidence on the long-term neurological outcomes of PeV-A encephalitis in infants.

## Key findings

- Most children with PeV-A encephalitis showed no neurodevelopmental sequelae at 24 months.
- Brain MRIs revealed no significant lesions in participants up to 12 months of age.
- Three infants had white matter alterations on MRI at discharge but no long-term effects were observed.

## Abstract

Human parechoviruses, officially known as Parechovirus A (PeV-A), are more frequently reported as a significant cause of serious infections in newborns and young infants. We aimed to describe the clinical features and neurological outcomes of PeV-A encephalitis cases identified in Warsaw. Infants with suspected encephalitis were retrospectively identified in three hospitals in the summer of 2022. Cases of confirmed PeV-A infection had their comprehensive demographic, clinical, laboratory, imaging, and outcome data reviewed. The psychomotor development of the children up to the age of 2 years was assessed by using the standardized tools. We identified 18 cases of confirmed encephalitis with a PeV-A infection. Their median age was 16 days. Fourteen cases were included in the analysis, while one patient dropped out after the first visit. Most were boys (9/14), and one patient was born preterm. Three patients had white matter alterations on brain MRI at discharge. No significant neurologic sequelae were observed after acute illness. At the 24-month follow-up, based on the Bayley Scales of Infant and Toddler Development (BSID-IV) and the Brunet–Lézine Scale, the children showed no neurodevelopmental sequelae. Brain MRIs were obtained in all of the participants up to 12 months of age and revealed no significant lesions. Neurodevelopmental complications are not frequent in children after PeV-A encephalitis at 24 months of age. Continued follow-up in larger cohorts is needed to explore the predictors of long-term morbidity.