# Influence of Wine on Bone Mineral Density

## TL;DR

This review suggests that light to moderate wine consumption may help improve bone density, but more research is needed to confirm these effects.

## Contribution

The study provides a critical review of wine's potential impact on bone mineral density, highlighting the need for future randomized trials.

## Key findings

- Light to moderate wine consumption may be associated with higher bone mineral density in the spine and femoral neck.
- Most studies supporting this link are observational, requiring further validation through randomized controlled trials.
- Non-alcoholic or low-alcohol wine alternatives with similar polyphenol content warrant exploration for bone health benefits.

## Abstract

Background: Considering the increasing interest in strategies to prevent osteoporosis and other bone-related conditions, it is relevant to critically assess the existing evidence on the potential benefits of phenolic compounds in wine on bone metabolism. Objectives: This integrative review aims to evaluate clinical and animal studies investigating the influence of wine consumption on bone mineral density (BMD). Methods: The search was conducted in PubMed, Scopus, and Embase databases until April 2025. The key question was: “Does wine consumption influence BMD?”. Results: After searching the identified databases, 108 studies were screened, and 7 were included in the final analysis. Conclusions: This review suggests a possible association between light to moderate wine consumption and favorable effects on BMD, particularly in the spine and femoral neck. However, these findings should be interpreted cautiously due to the predominance of observational studies. Future RCTs and systematic reviews must clarify wine’s potential role in bone health and explore non-alcoholic or low-alcohol wine alternatives with similar polyphenol content.