# Main Dietary Patterns for Healthy Aging and Well-Being

**Authors:** Graziano Vinci, Federica Davì, Teresina Pellegrino, Roberta Fusco, Marika Cordaro, Rosanna Di Paola

PMC · DOI: 10.3390/nu17122009 · Nutrients · 2025-06-16

## TL;DR

This paper reviews three dietary patterns—Mediterranean, plant-based, and Nordic—that may promote healthy aging and well-being.

## Contribution

The paper identifies shared foods across three diets and their potential roles in healthy aging through various biological pathways.

## Key findings

- Shared foods in the three diets may positively influence aging pathways and oxidative stress.
- Current research on these foods does not fully cover all aging-related biological processes.
- Further investigation is needed on key aging hallmarks like nutrient sensing and cellular senescence.

## Abstract

Life expectancy around the world has increased significantly in recent decades, but chronic diseases and an aging population have also grown considerably. Accordingly, the world’s research attention has increasingly focused on the study of possible dietary patterns that can promote healthy aging and the well-being of individuals. Method: This review exposes three different dietary patterns that share various foods which, individually, could promote healthy aging. Following an intensive literature search, the choice of dietary patterns included the Mediterranean diet, the plant-based diet, and the Nordic diet. Results: The foods selected in this review, with the aim of promoting healthy aging and individual well-being, are those shared by the three diet patterns (Mediterranean diet, plant-based diet, and Nordic diet). In particular, the possible positive effects of these foods were investigated through the study of various pathways involved in the aging process, as well as oxidative stress, which underlies aging itself. Conclusions: Although the results are very encouraging, as they show a beneficial effect of the aliments examined, to date, many hallmarks of aging, as well as its characteristic pathways, are not concretely investigated, especially considering the foods examined. For example, deregulated nutrient sensing, stem cell exhaustion, and cellular senescence are additional important hallmarks that are not currently examined.

## Full-text entities

- **Genes:** Cat (catalase) [NCBI Gene 12359] {aka 2210418N07, Cas-1, Cas1, Cs-1}, Mapk8 (mitogen-activated protein kinase 8) [NCBI Gene 26419] {aka JNK, JNK1, Prkm8, SAPK1}, Tnf (tumor necrosis factor) [NCBI Gene 21926] {aka DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa}, Nfe2l2 (nuclear factor, erythroid derived 2, like 2) [NCBI Gene 18024] {aka Nrf2}, Mapk14 (mitogen-activated protein kinase 14) [NCBI Gene 26416] {aka CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15}, Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) [NCBI Gene 18033] {aka NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105}, Casp3 (caspase 3) [NCBI Gene 12367] {aka A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32}, Parp1 (poly (ADP-ribose) polymerase family, member 1) [NCBI Gene 11545] {aka 5830444G22Rik, ARTD1, Adprp, Adprt1, PARP, PPOL}, Bax (BCL2-associated X protein) [NCBI Gene 12028], Tlr4 (toll-like receptor 4) [NCBI Gene 21898] {aka Lps, Ly87, Ran/M1, Rasl2-8}, CAT (catalase) [NCBI Gene 847], Mapk1 (mitogen-activated protein kinase 1) [NCBI Gene 26413] {aka 9030612K14Rik, ERK, Erk2, MAPK2, PRKM2, Prkm1}, Nos2 (nitric oxide synthase 2, inducible) [NCBI Gene 18126] {aka MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, Hmox1 (heme oxygenase 1) [NCBI Gene 15368] {aka D8Wsu38e, HO-1, HO1, Hemox, Hmox, Hsp32}, checkpoint kinase 2 [NCBI Gene 102184180], Glb1 (galactosidase, beta 1) [NCBI Gene 12091] {aka Bge, Bgl, Bgl-e, Bgl-s, Bgl-t, Bgs}, Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) [NCBI Gene 19017] {aka A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1}, Casp7 (caspase 7) [NCBI Gene 12369] {aka CMH-1, ICE-IAP3, Mch3, caspase-7, mCASP-7}, checkpoint kinase 1 [NCBI Gene 102184881], H2ax (H2A.X variant histone) [NCBI Gene 15270] {aka H2A.X, H2afx, Hist5-2ax, gammaH2ax}, Sirt1 (sirtuin 1) [NCBI Gene 93759] {aka SIR2L1, Sir2, Sir2a, Sir2alpha}, Foxo3 (forkhead box O3) [NCBI Gene 56484] {aka 1110048B16Rik, 2010203A17Rik, FKHRL1, Fkhr2, Foxo3a}, Trp53-ps (transformation related protein 53, pseudogene) [NCBI Gene 22060], Ppara (peroxisome proliferator activated receptor alpha) [NCBI Gene 19013] {aka 4933429D07Rik, Nr1c1, PPAR-alpha, PPARalpha, Ppar}, Il6 (interleukin 6) [NCBI Gene 16193] {aka Il-6}
- **Diseases:** chronic inflammation (MESH:D007249), sarcopenia (MESH:D055948), injury to (MESH:D014947), degenerative joint diseases (MESH:D019636), metabolic syndrome (MESH:D024821), fibrosis (MESH:D005355), OS (MESH:D000079225), iron overload (MESH:D019190), MD (MESH:D007161), HA (MESH:D000067329), poor vision (MESH:D014786), mitochondrial damage (MESH:D028361), Parkinson's disease (MESH:D010300), cardiovascular and cerebrovascular diseases (MESH:D002318), Alzheimer disease (MESH:D000544), cancer (MESH:D009369), dysbiosis (MESH:D064806), diabetes (MESH:D003920), sensory impairments (MESH:D012678), cytotoxic (MESH:D064420), age-related diseases (MESH:D010024), central nervous system disorders (MESH:D002493), gait and balance abnormalities (MESH:D020233), depression (MESH:D003866), obesity (MESH:D009765), ALFD (MESH:D005235), learning and memory impairment (MESH:D007859), HHcy (MESH:D020138), liver damage (MESH:D056486), chronic obstructive pulmonary disease (MESH:D029424), overweight (MESH:D050177), dementia (MESH:D003704), metabolic disorder (MESH:D008659), neurological alteration (MESH:D009461), hearing loss (MESH:D034381), necrosis (MESH:D009336), neuroblastoma (MESH:D009447), cognitive decline (MESH:D003072), chronic diseases (MESH:D002908)
- **Chemicals:** Olive Oil (MESH:D000069463), Tyrosol (MESH:C011867), hydrogen peroxide (MESH:D006861), L-methionine (MESH:D008715), AO (-), bergamot (MESH:C068336), linoleic acid (MESH:D019787), sugars (MESH:D000073893), PUFA (MESH:D005231), oxygen (MESH:D010100), sulfhydryl (MESH:D013438), lactic acid (MESH:D019344), polysaccharides (MESH:D011134), amino acids (MESH:D000596), HC (MESH:D006854), phenols (MESH:D010636), TG (MESH:D014280), Carbohydrates (MESH:D002241), malondialdehyde (MESH:D008315), polyphenol (MESH:D059808), ATP (MESH:D000255), GSH (MESH:D005978), carotenoids (MESH:D002338), iron (MESH:D007501), Oleocanthal (MESH:C503534), Lipids (MESH:D008055), LPS (MESH:D008070), essential oils (MESH:D009822), oleic acid (MESH:D019301), essential amino acids (MESH:D000601), OEA (MESH:C488250), oleuropein (MESH:C002769), thiobarbituric acid reactive substance (MESH:D017392), alcohol (MESH:D000438), NO (MESH:D009569), cholesterol (MESH:D002784), flavonoids (MESH:D005419), ethanol (MESH:D000431), ROS (MESH:D017382), hydroxytyrosol (MESH:C005975), D-galactose (MESH:D005690), vegetable oils (MESH:D010938)
- **Species:** Malus domestica (apple, species) [taxon 3750], Leptospira sp. AB (species) [taxon 103236], Olea (olives, genus) [taxon 4145], Rattus norvegicus (brown rat, species) [taxon 10116], Mus musculus (house mouse, species) [taxon 10090], Canis lupus familiaris (dog, subspecies) [taxon 9615], Lacticaseibacillus rhamnosus (species) [taxon 47715], Pyrus communis (pear, species) [taxon 23211], Homo sapiens (human, species) [taxon 9606], Avena sativa (cultivated oat, species) [taxon 4498], Theobroma cacao (cacao, species) [taxon 3641], Chenopodium quinoa (quinoa, species) [taxon 63459], Solanum tuberosum (potatoes, species) [taxon 4113], Citrus (genus) [taxon 2706], Anacardium occidentale (cashew, species) [taxon 171929], Ovis aries (domestic sheep, species) [taxon 9940], Bos taurus (bovine, species) [taxon 9913], Oryza sativa (Asian cultivated rice, species) [taxon 4530], Arachis hypogaea (goober, species) [taxon 3818], Capra hircus (domestic goat, species) [taxon 9925], Persea americana (avocado, species) [taxon 3435]
- **Cell lines:** SH-SY5Y — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0019), RAW 264.7 — Mus musculus (Mouse), Mouse leukemia, Cancer cell line (CVCL_0493), Hep52 — Homo sapiens (Human), Cervical carcinoma, Cancer cell line (CVCL_JB76)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12196176/full.md

## References

133 references — full list in the complete paper: https://tomesphere.com/paper/PMC12196176/full.md

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Source: https://tomesphere.com/paper/PMC12196176