# A Concise Asymmetric Synthesis of Sex Pheromone of Euproctis pseudoconspersa (Strand) and Its Enantiomer

## TL;DR

This paper presents a new and efficient method to synthesize the sex pheromone of the tea tussock moth and its mirror-image form.

## Contribution

A concise asymmetric synthesis method for the sex pheromone and its enantiomer using Evans’s template and Li2CuCl4-catalyzed coupling.

## Key findings

- The chiral methyl group was successfully introduced using Evans’s template.
- Carbon chain extension was achieved via Li2CuCl4-catalyzed coupling of chiral tosylate with Grignard reagent.
- The method provides both the pheromone and its enantiomer in a concise manner.

## Abstract

The tea tussock moth, Euproctis pseudoconspersa (Strand), is a serious pest, and its sex pheromone is (R)-10,14-dimethylpentadecyl isobutyrate. A new and concise asymmetric synthesis of the sex pheromone and its enantiomer was accomplished. The chiral methyl of the pheromone was introduced by Evans’s template, while the extension of the carbon chain was achieved through Li2CuCl4-catalyzed coupling of chiral tosylate with Grignard reagent.