# Effects of Remote Ischemic Conditioning on Cardiovascular Responsiveness in Healthy Individuals

## TL;DR

This study found that a single session of remote ischemic conditioning does not significantly affect cardiovascular responses in healthy individuals.

## Contribution

The novel contribution is the evaluation of RIC's impact on cardiovascular reactivity using passive leg raising in healthy volunteers.

## Key findings

- No significant differences in stroke volume response to passive leg raising before and after RIC.
- PLR significantly increased perfusion index both before and after RIC.
- RIC had no significant effect on peripheral perfusion index changes induced by PLR.

## Abstract

The remote ischemic conditioning (RIC)-induced changes in systemic hemodynamics or circulatory reactivity are unclear. Therefore, we aimed to evaluate the effect of a single bout of RIC on the passive leg raising (PLR)-induced cardiovascular response. This prospective study included 36 healthy volunteers (median age: 24 years). Systemic hemodynamic indices were assessed through the following sequential steps: with the participant in a supine position, during the first PLR maneuver, before RIC, after RIC, during the second PLR maneuver, and with the participant in a supine position. The perfusion index (PI) was measured during PLR before and after RIC. We found no significant differences before and after RIC in the proportion of responders during PLR (participants with stroke volume (SV) change ≥ 10%, 61% vs. 47%, p = 0.180). There was a strong correlation between SV changes during the two PLR tests (rs = 0.80, p < 0.001). PLR significantly increased the PI before and after RIC. However, there was no significant difference before and after RIC in the PLR-induced PI changes (p = 0.944). Our findings suggest that a single bout of RIC has no effect on PLR-induced cardiovascular responses in terms of changes in systemic hemodynamic and peripheral perfusion indices.