# Molecular Diplomacy of Lipids in the War of Immunity: Bridging Rare and Common Disease Mechanisms **Authors:** Manoj Kumar Pandey PMC · DOI: 10.3390/ijms26125568 · International Journal of Molecular Sciences · 2025-06-10 ## Full-text entities - **Genes:** UGT1A9 (UDP glucuronosyltransferase family 1 member A9) [NCBI Gene 54600] {aka HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, VCAM1 (vascular cell adhesion molecule 1) [NCBI Gene 7412] {aka CD106, INCAM-100}, RXRA (retinoid X receptor alpha) [NCBI Gene 6256] {aka NR2B1, RXR-alpha, RXRalpha}, CD44 (CD44 molecule (IN blood group)) [NCBI Gene 960] {aka CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL}, C5AR1 (complement C5a receptor 1) [NCBI Gene 728] {aka C5A, C5AR, C5R1, CD88}, NR1I2 (nuclear receptor subfamily 1 group I member 2) [NCBI Gene 8856] {aka BXR, ONR1, PAR, PAR1, PAR2, PARq}, SOX2 (SRY-box transcription factor 2) [NCBI Gene 6657] {aka ANOP3, MCOPS3}, CD47 (CD47 molecule) [NCBI Gene 961] {aka IAP, MER6, OA3}, CRIPTO3 (cripto, EGF-CFC family member 3) [NCBI Gene 6998] {aka CR-3, CRIPTO-3, TDGF1, TDGF1P3, TDGF2, TDGF3}, RET (ret proto-oncogene) [NCBI Gene 5979] {aka CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1}, CD34 (CD34 molecule) [NCBI Gene 947], C3 (complement C3) [NCBI Gene 718] {aka AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) [NCBI Gene 53947] {aka A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK}, IL17A (interleukin 17A) [NCBI Gene 3605] {aka CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, PECAM1 (platelet and endothelial cell adhesion molecule 1) [NCBI Gene 5175] {aka CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM}, IL12B (interleukin 12B) [NCBI Gene 3593] {aka CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF}, NANOG (Nanog homeobox) [NCBI Gene 79923], PROM1 (prominin 1) [NCBI Gene 8842] {aka AC133, CD133, CORD12, MCDR2, MSTP061, PROML1}, FUT4 (fucosyltransferase 4) [NCBI Gene 2526] {aka CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX}, C5 (complement C5) [NCBI Gene 727] {aka C5D, C5a, C5b, CPAMD4, ECLZB}, UGCG (UDP-glucose ceramide glucosyltransferase) [NCBI Gene 7357] {aka GCS, GLCT1}, CD24 (CD24 molecule) [NCBI Gene 100133941] {aka CD24A}, METTL3 [NCBI Gene 101108050], GBA1 (glucosylceramidase beta 1) [NCBI Gene 2629] {aka GBA, GCB, GLUC}, YAP1 (Yes1 associated transcriptional regulator) [NCBI Gene 10413] {aka COB1, YAP, YAP-1, YAP2, YAP65, YKI}, ULK1 (unc-51 like autophagy activating kinase 1) [NCBI Gene 8408] {aka ATG1, ATG1A, UNC51, Unc51.1, hATG1}, POU5F1 (POU class 5 homeobox 1) [NCBI Gene 5460] {aka OCT3, OCT4, OCT4Borf1, OTF-3, OTF3, OTF4}, PPARA (peroxisome proliferator activated receptor alpha) [NCBI Gene 5465] {aka NR1C1, PPAR, PPAR-alpha, PPARalpha, hPPAR}, C1QA (complement C1q A chain) [NCBI Gene 712] {aka C1QD1}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, FASN (fatty acid synthase) [NCBI Gene 2194] {aka FAS, OA-519, SDR27X1}, C3AR1 (complement C3a receptor 1) [NCBI Gene 719] {aka AZ3B, C3AR, HNFAG09}, TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase) [NCBI Gene 6901] {aka BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, THY1 (Thy-1 cell surface antigen) [NCBI Gene 7070] {aka CD90, CDw90}, EPCAM (epithelial cell adhesion molecule) [NCBI Gene 4072] {aka Ber-Ep4, BerEp4, DIAR5, EGP-2, EGP314, EGP40}, LGR5 (leucine rich repeat containing G protein-coupled receptor 5) [NCBI Gene 8549] {aka FEX, GPR49, GPR67, GRP49, HG38}, SLC27A2 (solute carrier family 27 member 2) [NCBI Gene 11001] {aka ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS}, ICAM1 (intercellular adhesion molecule 1) [NCBI Gene 3383] {aka BB2, CD54, P3.58} - **Diseases:** sepsis (MESH:D018805), hypoxia (MESH:D000860), organ damage (MESH:D000092124), fatty liver (MESH:D005234), neuropathies (MESH:D009422), genetic diseases (MESH:D030342), damage (MESH:D020263), endothelial dysfunction (MESH:D014652), rheumatoid arthritis (MESH:D001172), hemolytic-uremic syndrome (MESH:D006463), melanoma (MESH:D008545), lupus nephritis (MESH:D008181), renal and cardiac complications (MESH:D006331), Niemann-Pick disease type C (MESH:D052556), obesity (MESH:D009765), lipid storage (MESH:C562935), tissue injury (MESH:D017695), immunological dysregulation (MESH:D007154), oncologic diseases (MESH:D000072716), Pompe disease (MESH:D006009), membranous nephropathy (MESH:D015433), SLE (MESH:D008180), cardiovascular disorders (MESH:D002318), metabolic disease (MESH:D008659), multi-organ failure (MESH:D009102), infection (MESH:D007239), injury (MESH:D014947), Fabry (MESH:D000795), chronic inflammation (MESH:D007249), Cancer (MESH:D009369), dyslipidemia (MESH:D050171), RA (MESH:D011015), AMD (MESH:D008268), complement dysregulation (OMIM:614878), Gaucher disease (MESH:D005776), metastases (MESH:D009362), ARDS (MESH:D012128), toxicity (MESH:D064420), metabolic insufficiency (MESH:D000309), bacterial infection (MESH:D001424), LSDs (MESH:D016464), complement system (MESH:D007153), neuroinflammation (MESH:D000090862) - **Chemicals:** fatty acid (MESH:D005227), globotriaosylceramide (MESH:C018549), PEG400 (MESH:C000595213), Avacopan (MESH:C000620232), 5-methylcytosine (MESH:D044503), eculizumab (MESH:C481642), ROS (MESH:D017382), retinol (MESH:D014801), glucose (MESH:D005947), Lipid (MESH:D008055), LPS (MESH:D008070), N6-methyladenosine (MESH:C010223), pegcetacoplan (MESH:C000716074), C3b (-), retinoic acid (MESH:D014212), GC (MESH:D005963), bile acid (MESH:D001647) - **Species:** Mus musculus (house mouse, species) [taxon 10090], Ovis aries (domestic sheep, species) [taxon 9940], Homo sapiens (human, species) [taxon 9606] - **Mutations:** serine/threonine, V600E ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12193406/full.md ## References 55 references — full list in the complete paper: https://tomesphere.com/paper/PMC12193406/full.md --- Source: https://tomesphere.com/paper/PMC12193406