# Serum OxLDL Levels Are Positively Associated with the Number of Ischemic Events and Damaged Blood Vessels in Patients with Coronary Artery Disease

## TL;DR

Higher levels of oxidized LDL in the blood are linked to more ischemic events and damaged blood vessels in coronary artery disease patients.

## Contribution

This study shows a direct link between elevated oxLDL levels and increased disease severity in CAD patients.

## Key findings

- CAD patients with ≥2 ischemic events and ≥2 damaged blood vessels had significantly higher oxLDL levels.
- OxLDL levels were positively correlated with the number of ischemic events and damaged blood vessels.
- The study provides evidence that oxLDL is a potential biomarker for CAD severity.

## Abstract

Background/Objectives: The severity of coronary artery disease (CAD) depends on several factors. Oxidative stress contributes to the oxidation of lipoproteins, thereby promoting ischemic events (IEs) and damaged blood vessels (DBVs). This study aimed to compare biochemical variables and levels of oxidized lipoproteins in CAD patients stratified by the number of IEs and DBVs. Methods: A cross-sectional study was performed, including 51 patients diagnosed with CAD. Serum oxidized lipoproteins were measured by ELISA. Results: CAD patients with ≥2 IEs and ≥2 DBVs showed higher oxLDL levels than those with one IE and one DBV (8293.35 ng/mL [7131.32–9287.39] vs. 6474.26 ng/mL [5374.52–7574.01], p = 0.029). OxLDL levels were positively associated with the number of IEs (r2 = 15.2, B = 0.142 [0.046–0.239], p = 0.005) and DBVs (r2 = 19.2, B = 0.196 [0.018–0.374], p = 0.020). Conclusions: This study identified a positive association between elevated serum oxLDL levels and the presence of ≥2 IEs and ≥2 DBVs in CAD patients.