# Coping Styles and Defense Mechanisms in Healthy Young Adults—Correlations with tPA-BDNF Pathway

## TL;DR

This study explores how stress-coping strategies in young adults are linked to specific proteins in the tPA-BDNF pathway, suggesting biological connections to psychological responses.

## Contribution

The study identifies novel correlations between tPA-BDNF pathway proteins and coping styles or defense mechanisms in healthy individuals.

## Key findings

- Higher BDNF and lower MMP-9 levels were observed in females.
- Correlations were found between protein levels and coping strategies like denial and active coping.
- DSQ-40 scores correlated with BDNF, proBDNF, MMP-9, and total serpin E1/PAI-1.

## Abstract

Background/Objectives: An increasing number of studies are exploring how stress influences the development of various psychiatric and physical disorders. Psychological coping strategies and defense mechanisms play a vital role in managing stress. However, the biological mechanisms involved in coping with stress have not been thoroughly researched. This study focuses on the relationships between plasma levels of tPA-BDNF pathway proteins and their correlations with coping strategies and defense mechanisms. Methods: The study involved 48 healthy young adults. All participants completed the self-reported Defense Style Questionnaire (DSQ-40) and Coping Orientation to Problems Experienced Inventory (COPE). BDNF, proBDNF, t-plasminogen activator/tPA, total serpin E1/PAI-1, serpin F2/alpha 2-antiplasmin, and MMP-9 plasma concentrations were determined using ELISA. Results: We detected higher BDNF and lower MMP-9 levels in females. We found differences in the DSQ-40 humor subdimension and in the COPE focus on and venting of emotions category between women and men. We found correlations between studied protein plasma concentrations. Positive correlations of total serpin E1/PAI-1 with denial and mental disengagement and negative correlations with some active coping categories were found. Correlations of DSQ-40 scores with BDNF, proBDNF, MMP-9, and total serpin E1/PAI-1 were detected. Conclusions: Our findings indicate that there are functional associations between the proteins we studied and various coping styles, as well as mature, immature, and neurotic defense mechanisms.