# Use of Impella RP Flex in Post-Heart Transplant Patients with RV Primary Graft Dysfunction

## TL;DR

This study evaluates the use of the Impella RP Flex device to treat right ventricular dysfunction after heart transplants, finding it effective but noting significant bleeding and kidney issues.

## Contribution

The study provides clinical evidence on the safety and effectiveness of the Impella RP Flex for treating RV-PGD post-heart transplant.

## Key findings

- Five patients with RV-PGD showed recovery of right ventricular function after an average of 8.6 days of Impella RP Flex support.
- Common complications included hemolysis, bleeding, and acute kidney dysfunction requiring hemodialysis.
- No tricuspid valve injuries were observed, and one device showed transient biologic material ingestion during weaning.

## Abstract

Background: Right ventricular primary graft dysfunction (RV-PGD) is a rare but serious complication following heart transplantation, associated with a high morbidity and mortality. Temporary mechanical circulatory support is indicated when patients fail to respond to pharmacological therapy. This study aimed to evaluate the outcomes of patients with RV-PGD who received RV mechanical support with the Impella RP Flex device at our institution. Methods: Medical records of patients with RV-PGD supported by the Impella RP Flex device between December 2022 and March 2024 were reviewed retrospectively to assess survival, procedural complications, duration of support, and end organ dysfunction. Results: Of the 20 patients reviewed, 5 met the inclusion criteria. All five patients demonstrated recovery of RV function after a mean support duration of 8.6 ± 3.05 days. One pump showed transient evidence of biologic material ingestion during a weaning trial. No cases of tricuspid valve injury were observed. The most common complications were hemolysis, bleeding, and acute kidney dysfunction, with all patients requiring hemodialysis. Conclusions: Impella RP Flex support is safe and effective for managing primary and isolated RV-PGD without the need for additional blood oxygenation. However, bleeding complications requiring intervention remain a significant concern, and further evaluation of renal recovery is warranted.