TRIB1 and TRPS1 Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations

TL;DR

This study shows that specific gene variations in TRPS1 and TRIB1 are linked to higher risk of heart disease and changes in blood lipid levels.

Contribution

The study identifies novel associations between TRPS1 and TRIB1 gene polymorphisms and acute coronary syndrome risk through lipid profile changes.

Findings

SNPs rs2737229, rs2980880, and rs2954029 are associated with increased risk of acute coronary syndrome.

Minor alleles of these SNPs correlate with elevated plasma lipid levels in control subjects.

TRPS1 and TRIB1 genes likely contribute to coronary heart disease risk via lipid profile modulation.

Abstract

Coronary heart disease is the main cause of mortality in the world, so the early screening of patients at high risk is a priority. In this context, genome-wide association and case–control studies have revealed that the presence of polymorphic sites in the transcriptional repressor GATA binding 1 (rs231150 A/T and rs2737229 A/C) and tribbles pseudokinase 1 (rs2980880 T/C and rs2954029 T/A) genes are associated with a predisposition to CAD and with plasma lipid profile levels. Therefore, here, we investigated whether these polymorphisms are associated with CAD clinical events. Our findings demonstrated that rs2737229 A/C, rs2980880 T/C, and rs2954029 T/A polymorphisms were associated with the risk of acute coronary syndrome development and with changes in plasma lipid levels. Such associations suggest that these genes are involved in the risk of CAD, probably through an increase in plasma lipid levels.

In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (TRPS1) and tribbles pseudokinase 1 (TRIB1) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). The aim of this work was to explore whether single nucleotide polymorphisms (SNPs) in the TRSP1 (rs231150 and rs2737229) and TRIB1 (rs2980880 and rs2954029) genes are involved in acute coronary syndrome (ACS) and plasma lipid levels. We included 1262 patients diagnosed with ACS and 1051 controls. According to inheritance models, the minor alleles of the SNPs (rs2737229 A, rs2980880 C, and rs2954029 T) were associated with an increased incidence of ACS (p < 0.05). In a sub-analysis that included only the control subjects, the same minor allele frequency was associated with increased total cholesterol, HDL-cholesterol, and LDL-cholesterol levels and low triglyceride levels. In conclusion, rs2737229, rs2980880, and rs2954029 polymorphisms are associated with a risk of developing ACS and with elevated plasma lipid levels. Our results suggest that the TRSP1 and TRIB1 are implicated in the incidence of ACS through of increased of plasma lipid profile.