# Complicated Pyelonephritis Leading to Vertebral Osteomyelitis: Diagnostic and Therapeutic Considerations

## TL;DR

A case shows how kidney infection can lead to spinal infection, stressing the need for careful treatment and multidisciplinary care.

## Contribution

Highlights diagnostic and therapeutic challenges in complicated pyelonephritis progressing to vertebral osteomyelitis.

## Key findings

- Pyelonephritis can progress to vertebral osteomyelitis via hematogenous spread.
- Antibiotic therapy duration is complex in cases with abscess formation and recurrent bacteraemia.
- Early transition to oral antibiotics may be insufficient for complicated vertebral infections.

## Abstract

This case illustrates the significant progression of pyelonephritis to vertebral osteomyelitis secondary to Escherichia coli bacteraemia, highlighting the potential for hematogenous dissemination from urinary tract infections to the spine. A female patient in her 60s initially presented with fever, nausea, and diarrhoea, subsequently diagnosed with E. coli bacteraemia from pyelonephritis. Despite initial clinical improvement with intravenous and oral antibiotics, her condition deteriorated over three hospital admissions, progressing to L1/L2 vertebral osteomyelitis complicated by bilateral psoas and epidural abscesses. Her functional status markedly declined from independent ambulation to requiring assistance for mobilization. This case emphasizes critical lessons regarding the complexity of determining optimal antibiotic therapy duration, especially when complicated by abscess formation and recurrent bacteraemia. It further underscores limitations associated with early transitions from intravenous to oral antibiotics in complicated vertebral infections, advocating heightened clinical vigilance and a multidisciplinary approach to prevent diagnostic delays and severe functional impairment.