# Efficacy of Ferrous Sulphate in the Management of Iron Deficiency Anemia in Children

**Authors:** Karishma Siraj, Faryal Naz, Shabnam Mahsood, Haseena Ali, Fatima Shafiq, Seema Nawaz, Khadija Manzar, Aizaz Ur Rahman, Sana Siraj, Tahir Hassan

PMC · DOI: 10.7759/cureus.84826 · Cureus · 2025-05-26

## TL;DR

This study shows that ferrous sulfate effectively improves anemia and iron levels in children with iron deficiency anemia.

## Contribution

The study provides empirical evidence on the efficacy of ferrous sulfate in treating pediatric iron deficiency anemia.

## Key findings

- Ferrous sulfate increased hemoglobin levels by an average of 3.11 mg/dl after three months.
- Serum ferritin levels rose by 5.9 ng/ml following treatment with ferrous sulfate.
- Low hemoglobin levels were positively associated with underweight status in children.

## Abstract

Background

Iron deficiency anemia (IDA) is a highly prevalent disorder among the pediatric population and has a significant impact on growth and health. Ferrous sulfate is commonly prescribed for the treatment of IDA; however, its efficacy in the pediatric population requires further research.

Objective

This study aimed to evaluate the efficacy of ferrous sulfate in improving hemoglobin (Hb) and ferritin levels in children diagnosed with IDA.

Methods

A quasi-experimental study was conducted involving 108 participants aged 1-8 years who were diagnosed with IDA. Participants received ferrous sulfate supplements for three months. Hemoglobin and serum ferritin levels were measured both at baseline and after three months of treatment.

Results

Ferrous sulfate administration resulted in a significant increase in hemoglobin levels by an average of 3.11 mg/dl and a net increase in ferritin levels by 5.9 ng/ml after 3 months of treatment. Additionally, a positive association was found between low Hb levels and underweight children.

Conclusion

Ferrous sulfate is an effective therapeutic agent for managing IDA in children, leading to significant improvements in hemoglobin and ferritin levels. Further research involving RCTs with longer follow-up periods is recommended.

## Linked entities

- **Chemicals:** ferrous sulfate (PubChem CID 24393)
- **Diseases:** Iron deficiency anemia (MONDO:0001356)

## Full-text entities

- **Diseases:** IDA (MESH:D018798)
- **Chemicals:** Ferrous Sulphate (MESH:C020748)

## Full text

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## Figures

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12188945/full.md

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Source: https://tomesphere.com/paper/PMC12188945