# A meta-analysis of randomized controlled trials examining the effectiveness of carbetocin in reducing intraoperative blood loss during abdominal myomectomy

## TL;DR

This study finds that carbetocin reduces blood loss and complications during abdominal myomectomy surgeries compared to no treatment.

## Contribution

A meta-analysis showing carbetocin's effectiveness in reducing intraoperative blood loss during abdominal myomectomy.

## Key findings

- Carbetocin significantly reduced intraoperative blood loss by 292.27 mL compared to control.
- The drug also decreased blood transfusion rates and operation time.
- No major toxicities were reported with carbetocin use.

## Abstract

This study aimed to systematically review and meta-analyze randomized controlled trials (RCTs) assessing the clinical efficacy and safety of carbetocin compared to passive control (placebo or no treatment) in the context of abdominal myomectomy.

Six sources of information underwent screening until 13 April 2024. The risk of bias was assessed using the Cochrane Collaboration tool. The results were presented as mean difference (MD) or risk ratio (RR) along with a 95% confidence interval (CI) using a random-effects model.

Five RCTs with 6 arms and 484 patients (carbetocin = 262 and control = 222) were analyzed. The overall risk of bias was “low” in two studies and “some concerns” in three studies. The carbetocin group exhibited significantly lower mean intraoperative blood loss (n = 6 arms, MD = –292.27 mL, 95% CI [−372.5, −212.03], p < 0.001, with very low certainty of evidence), mean change in hemoglobin (n = 6 arms, MD = –0.63 g/dL, 95% CI [−0.94, −0.33], p < 0.001, with low certainty of evidence), rate of blood transfusion (RR = 0.3, 95% CI [0.21, 0.44], p < 0.001, with very low certainty of evidence), and mean operation time (n = 5 arms, MD = −22.98 min, 95% CI [−38.93, −7.02], p < 0.001, with low certainty of evidence). There was no significant difference between both groups regarding the mean hospital stay (n = 2 arms, MD = –0.1 days, 95% CI [−0.27, 0.06], p = 0.21). The sensitivity analyses demonstrated robustness across all outcomes. No major toxicities were reported.

Carbetocin use was tolerable and associated with considerable declines in intraoperative blood loss and related complications compared with passive control intervention during abdominal myomectomy.