# Dermoscopy of Solitary Multinucleate Cell Angiohistiocytoma: A Rare Amelanotic Clinical Imitator of Melanoma

**Authors:** Georgios Sarris, Zannis Almpanis, Zoe Apalla, Alexander Katoulis, Dimitrios Sgouros

PMC · DOI: 10.7759/cureus.84796 · Cureus · 2025-05-25

## TL;DR

This paper describes a rare skin condition called MCAH that looks like melanoma but is benign, focusing on its appearance and diagnosis.

## Contribution

The paper provides a detailed case report highlighting the dermoscopic features of solitary MCAH.

## Key findings

- MCAH can clinically mimic melanoma but is benign.
- Dermoscopic features help distinguish MCAH from more aggressive tumors.
- Histopathological and immunohistochemical analysis is essential for confirmation.

## Abstract

Multinucleate cell angiohistiocytoma (MCAH) is a rarely reported and likely underdiagnosed cutaneous entity with benign biological behavior. MCAH is described as a solitary or multiple proliferation of vascular and fibrohistiocytic origin, with largely unknown etiopathogenesis. It presents as red-brown to violaceous papules or nodules, mainly on the extremities, and is usually asymptomatic. A definitive diagnosis of MCAH requires specific histopathological and immunohistochemical findings. The following report presents a case of solitary MCAH with the aim of clarifying the clinical, histological, and especially dermoscopic aspects of this dermatological disorder, which may resemble more aggressive skin tumors.

## Linked entities

- **Diseases:** melanoma (MONDO:0005105)

## Full-text entities

- **Diseases:** skin tumors (MESH:D012878), MCAH (MESH:D000742), Melanoma (MESH:D008545), dermatological disorder (MESH:D000168)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12187247/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12187247/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12187247/full.md

---
Source: https://tomesphere.com/paper/PMC12187247