Brain natriuretic peptide and all-cause mortality in patients treated with haemodialysis

TL;DR

This study explores how brain natriuretic peptide (BNP) and fluid overload relate to mortality in patients undergoing hemodialysis for chronic kidney disease.

Contribution

The study identifies age, inflammation, and handgrip strength as stronger predictors of mortality than BNP in hemodialysis patients.

Findings

BNP was initially correlated with all-cause mortality in hemodialysis patients.

After adjusting for other factors, age, handgrip strength, and CRP were found to be more significant predictors of mortality than BNP.

Fluid overload was not significantly associated with all-cause mortality in this study.

Abstract

Brain natriuretic peptide (BNP) is a hormone secreted from the heart in response to fluid overload. In patients with chronic kidney disease (CKD), inadequate fluid management during haemodialysis may cause fluid overload and overhydration (OH), risk factors for mortality. The aim of this exploratory pilot study was to analyse the relationships between BNP, OH and all-cause mortality in patients with CKD and haemodialysis.

In this prospective observational study, five-year survival was analysed in 64 patients with CKD and haemodialysis. Bivariate correlations were performed to analyse the relationships between BNP, OH, and all-cause mortality. Cox regression analysis was performed to adjust the relationship between BNP and all-cause mortality for selected clinical and biochemical characteristics, collected at baseline.

By the end of the study, 33 patients (52%) had died. In bivariate correlation analysis age (r = 0.38), BNP (r = 0.48), handgrip strength (r=-0.34), lean tissue index (r=-0.41) and CRP level (r=-0.34, p = 0.007) were significantly associated with all-cause mortality. In a linear regression model, BNP was found to be a significant predictor of all-cause mortality (HR 2.61). However, after adjusting for age, handgrip strength, and CRP, BNP was no longer a statistically significant predictor of all-cause mortality. Instead, age, handgrip strength and CRP were significant predictors of all-cause mortality (HR 1.04; HR 0.95 and HR 2.61, respectively).

In this study, BNP was correlated with all-cause mortality in patients with CKD and haemodialysis, but OH was not. When adjusting for other clinical and biochemical factors, age, inflammation, and handgrip strength were found to be independent and more important predictors of all-cause mortality than BNP.

The online version contains supplementary material available at 10.1186/s12882-025-04251-8.

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