# An Extremely Rare Case of Squamous Cell Carcinoma Following Treatment for External Auditory Canal Papilloma

**Authors:** Yumi Ohta, Yoshiyuki Ozono, Motoyuki Suzuki, Takashi Sato, Hidenori Inohara

PMC · DOI: 10.7759/cureus.84755 · 2025-05-24

## TL;DR

A rare case of squamous cell carcinoma developed in a woman's ear canal after prior treatment for a papilloma and earlier radiotherapy.

## Contribution

This paper presents an extremely rare case of radiation-induced squamous cell carcinoma following prior treatment for a papilloma.

## Key findings

- A squamous cell carcinoma developed 9 years after papilloma excision and 20 years after radiotherapy.
- The case highlights the need for early diagnosis and multiple biopsies in suspected auditory canal malignancies.
- Re-irradiation is not feasible for radiation-induced cancers, emphasizing the importance of curative resection.

## Abstract

The case is of a 60-year-old woman with a history of radiotherapy for parotid adenoid cystic carcinoma. Twenty years after irradiation, a papilloma developed in the left external auditory canal. Nine years after excision of the papilloma, a squamous cell carcinoma developed in the same region. This is a rare case of squamous cell carcinoma following treatment for a papilloma and is considered radiation-induced cancer. Because re-irradiation is not possible as a treatment for radiation-induced cancer, it is necessary to diagnose the cancer early so that curative resection is possible. Multiple biopsies should be considered when malignancy is suspected because a single biopsy may not be sufficient to diagnose an auditory canal tumor.

## Linked entities

- **Diseases:** parotid adenoid cystic carcinoma (MONDO:0006356), papilloma (MONDO:0002363), squamous cell carcinoma (MONDO:0005096)

## Full-text entities

- **Diseases:** auditory canal tumor (MESH:D009369), Squamous Cell Carcinoma (MESH:D002294), adenoid cystic carcinoma (MESH:D003528), Auditory Canal Papilloma (MESH:D010212)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12185161/full.md

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Source: https://tomesphere.com/paper/PMC12185161