# Unveiling the Masquerader: A Rare Case of Pigmented Erythroplasia of Queyrat With Successful Multimodal Treatment

**Authors:** Mouna Guechchati, Zakia Douhi, Jaafar Marrakchi Benjaafar, Sara Elloudi, FatimaZahra Mernissi

PMC · DOI: 10.7759/cureus.84749 · 2025-05-24

## TL;DR

This paper presents a rare case of pigmented erythroplasia of Queyrat successfully treated with a combination of photodynamic therapy and surgery.

## Contribution

The novelty lies in demonstrating a successful conservative multimodal treatment approach for a rare and misdiagnosed condition.

## Key findings

- Pigmented erythroplasia of Queyrat was accurately diagnosed using dermoscopy and histology.
- A treatment combining photodynamic therapy and reconstructive surgery was effective in treating the condition.

## Abstract

Pigmented erythroplasia of Queyrat (EQ) is a rare variant of in situ squamous cell carcinoma that can clinically and dermoscopically mimic melanoma, which makes it hard to diagnose. We report the case of a 66-year-old man with a slowly progressive pigmented penile plaque. Dermoscopy and histology confirmed the diagnosis of pigmented EQ. The patient was successfully treated with photodynamic therapy followed by reconstructive surgery. This case highlights the importance of considering pigmented EQ in the differential diagnosis of genital pigmented lesions and illustrates the effectiveness of a conservative multimodal approach.

## Linked entities

- **Diseases:** melanoma (MONDO:0005105), squamous cell carcinoma (MONDO:0005096)

## Full-text entities

- **Diseases:** pigmented (MESH:D010859), EQ (MESH:D004919), in situ squamous cell carcinoma (MESH:D002294), genital pigmented lesions (MESH:D000091662), melanoma (MESH:D008545)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12185035/full.md

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Source: https://tomesphere.com/paper/PMC12185035