# [Retracted] Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway

**Authors:** Kun Ma, Chuan Zhang, Man-Yu Huang, Wu-Yin Li, Guo-Qiang Hu

PMC · DOI: 10.3892/or.2025.8928 · 2025-06-16

## Full-text entities

- **Genes:** MAPK14 (mitogen-activated protein kinase 14) [NCBI Gene 1432] {aka CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2}, MAPK8 (mitogen-activated protein kinase 8) [NCBI Gene 5599] {aka JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8}
- **Diseases:** osteosarcoma (MESH:D012516)
- **Chemicals:** ROS (-), Cinobufagin (MESH:C002471)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** U2OS — Homo sapiens (Human), Osteosarcoma, Cancer cell line (CVCL_0042)

---
Source: https://tomesphere.com/paper/PMC12183500