# A case with congenital absence of the left atrial appendage

**Authors:** Kosuke Muto, Naomichi Tanaka, Hitoshi Mori, Yoshifumi Ikeda, Ritsushi Kato

PMC · DOI: 10.1002/joa3.70120 · 2025-06-23

## TL;DR

This paper presents a rare case of a person born without a left atrial appendage and discusses its impact on managing heart conditions like atrial fibrillation.

## Contribution

The novelty lies in highlighting the rare anatomical variation and its clinical implications, particularly in AF management.

## Key findings

- Congenital absence of the left atrial appendage is extremely rare.
- The right atrial appendage may compensate for atrial natriuretic peptide production in such cases.

## Abstract

Congenital absence of the left atrial appendage (LAA) is an extremely rare anatomical variation with important implications for the management of atrial fibrillation (AF). Additionally, atrial natriuretic peptide (ANP) production may be compensated by the right atrial appendage (RAA) in cases of congenital LAA deficiency.

## Linked entities

- **Diseases:** atrial fibrillation (MONDO:0004981)

## Full-text entities

- **Genes:** NPPA (natriuretic peptide A) [NCBI Gene 4878] {aka ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF}
- **Diseases:** Congenital absence of the left atrial appendage (MESH:D059446), AF (MESH:D001281)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12183463/full.md

---
Source: https://tomesphere.com/paper/PMC12183463