HLA DRB1* Allele Lupus Erythematosus, Rheumatoid Arthritis, and other Autoimmune Disorders with Skin Involvement

TL;DR

This paper reviews how specific HLA DRB1 alleles are linked to various autoimmune diseases, especially those affecting the skin.

Contribution

The paper identifies specific DRB1 alleles associated with autoimmune disorders and highlights their role in skin-related immune conditions.

Findings

DRB1*16:02 is linked to systemic lupus erythematosus and myasthenia gravis.

DRB1*04 is associated with lupus erythematosus, bullous pemphigoid, and pemphigus vulgaris.

DRB1 alleles are connected to several skin-related autoimmune disorders but not psoriasis.

Abstract

A narrative short review has been made aiming to identify the most important immune disorders associated with the HLA DRB1*allele.

Data have been taken from PubMed, and 36 articles have been retrieved.

It has been found that DRB1*16:02 is associated with autoimmune diseases with production of autoantibodies, mainly systemic lupus erythematosus and myasthenia gravis. DRB1*04 is associated with lupus erythematosus, bullous pemphigoid, and pemphigus vulgaris. DRB1*is also associated with dermatitis herpetiformis, alopecia areata, acute generalised exanthematous pustulosis, and systemic sclerosis. No association of DRB1 has been found either with psoriasis or with psoriatic arthritis, while the association of Cw6 and DRB1*07 confers less severe joint damage in patients with psoriatic arthritis.

DRB1* is associated with lupus erythematosus rheumatoid arthritis and with most immune disorders with skin involvement.

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