A Case of Necrotizing Lymphadenitis From Streptococcus pyogenes

TL;DR

A rare case of necrotizing lymphadenitis caused by Streptococcus pyogenes is presented, highlighting the need to consider bacterial causes in such conditions.

Contribution

This is only the second reported case of necrotizing lymphadenitis caused by Streptococcus pyogenes.

Findings

A 25-year-old female presented with necrotizing lymphadenitis caused by Streptococcus pyogenes.

The patient's lymph node increased in size despite antibiotic treatment, requiring aspiration and biopsy.

Only one other case of this condition caused by S. pyogenes has been previously documented.

Abstract

Necrotizing lymphadenitis (NL) is a rare occurrence of necrotic, nongranulomatous lymphadenopathy. While idiopathic, autoimmune, and viral etiologies are commonly implicated in NL, bacterial etiologies, particularly from Streptococcus pyogenes (S. pyogenes), are exceedingly rare. We present a case of a 25-year-old female who presented with a one-week history of right-sided neck pain, fever, and sepsis. Examination and lab tests revealed an enlarged cervical lymph node measuring 2.4 cm and a positive Streptococcus A test. Four days later, the lymph node increased in size to 3.6 cm despite antibiotic management. Due to concerns of abscess formation and compression of the internal jugular vein, the patient underwent ultrasound-guided lymph node aspiration and biopsy, which revealed purulent fluid and necrosis. In our literature search, only one other case of NL secondary to S. pyogenes has been described, thus highlighting the clinical significance of this presentation. This case emphasizes the complexity of addressing and treating NL and underscores the need to consider bacterial etiologies in the diagnosis.

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